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For an example of how Circos can be used in genomics, see the Guide to Use in Genomics and Sequence Analysis.▴ Circos has features that makes it ideal for drawing genomic information.In the review article End-joining, Translocations and Cancer, Bunting and Nussenzweig demonstrate how compositing the genome circularly adds value and clarity to the presentation. use Circos to show the genomic structures, chromosome painting and comparative genomic mapping in C. The cover art for the issue shows a Circos plot of 90 significantly recurrent molecular alterations in prostate cancer from an analysis of 372 prostate tumors discussed in the Wyatt et al. The review summarizes the current state of understanding of prostate cancer, "including the sentinel role of copy number variation, the growing spectrum of oncogenic fusion genes, the potential influence of chromothripsis, and breakthroughs in defining mutation-associated subtypes.Increasing evidence suggests that genomic lesions frequently converge on specific cellular functions and signalling pathways, yet recurrent gene aberration appears rare". Another source of images are the Circos news section and published image section.The latter property is due to the nanoscopic closely packed protuberances of its self-cleaning leaf surface, which have been adapted for the manufacture of a self-cleaning industrial paint, Lotusan. describe the effects of the Deepwater Horizon blowout on the microbial blooms of petroleum-degrading bacteria.By sequencing 66 million community transcripts, the identity of metabolically active microbes and their roles in petroleum consumption was revealed. introduce a new type of visualization based on Circos, the interchange diagram, in their paper Visualizing Interchange Patterns in Massive Movement Data.The look of the image is inspired after Nature's Encode cover by Carl De Torres.

The conclusion warns us that "if regulatory policies do not account for embodied imports, global emissions are likely to rise even if developed countries emitters enforce strong national emissions targets." The pleasing roundness of Circos is used by Ming et al.In October 2013 Circos reached a milestone - 500 citations in peer-reviewed literature.To celebrate, I've made a commemorative poster that features over 400 Circos images from the literature.to depict the Sacred Lotus genome in the publication "Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.).

The Sacred lotus has religious significance in both Buddhism and Hinduism and has been used as a food and herbal medicine product in Asia for over 7,000 years.July 2013 The Fall 2013 issue of UCSF Magazine has my Circos illustration of personalized medicine.



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